CALL FOR PAPERS Integrative and Translational Physiology: Inflammation and Immunity in Organ System Physiology TLR3 deficiency induces chronic inflammatory cardiomyopathy in resistant mice following coxsackievirus B3 infection: role for IL-4
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چکیده
Eric D. Abston, Michael J. Coronado, Adriana Bucek, Jennifer A. Onyimba, Jessica E. Brandt, J. Augusto Frisancho, Eunyong Kim, Djahida Bedja, Yoon-kyu Sung, Andrea J. Radtke, Kathleen L. Gabrielson, Wayne Mitzner, and DeLisa Fairweather Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health and School of Medicine, Baltimore, Maryland; Department of Pathology, Johns Hopkins University, Bloomberg School of Public Health and School of Medicine, Baltimore, Maryland; and W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University, Bloomberg School of Public Health and School of Medicine, Baltimore Maryland
منابع مشابه
Th2 Regulation of Viral Myocarditis in Mice: Different Roles for TLR3 versus TRIF in Progression to Chronic Disease
Viral infections are able to induce autoimmune inflammation in the heart. Here, we investigated the role of virus-activated Toll-like receptor (TLR)3 and its adaptor TRIF on the development of autoimmune coxsackievirus B3 (CVB3) myocarditis in mice. Although TLR3- or TRIF-deficient mice developed similarly worse acute CVB3 myocarditis and viral replication compared to control mice, disease was ...
متن کاملCoxsackievirus B3 induces T regulatory cells, which inhibit cardiomyopathy in tumor necrosis factor-alpha transgenic mice.
Innate immunity promotes both the generation of autoimmunity and immunoregulation of adaptive immunity. Transgenic mice expressing the tumor necrosis factor-alpha (TNF-alpha) gene under the cardiac myosin promoter (TNF1.6 mice) develop dilated cardiomyopathy. Transgenic mice show extensive cardiac inflammation, suggesting that immunopathogenic mechanisms may promote cardiomyopathy. Two coxsacki...
متن کاملCoxsackievirus B3 Induces T Regulatory Cells, Which Inhibit Cardiomyopathy in Tumor Necrosis Factor- Transgenic Mice
Innate immunity promotes both the generation of autoimmunity and immunoregulation of adaptive immunity. Transgenic mice expressing the tumor necrosis factor(TNF ) gene under the cardiac myosin promoter (TNF1.6 mice) develop dilated cardiomyopathy. Transgenic mice show extensive cardiac inflammation, suggesting that immunopathogenic mechanisms may promote cardiomyopathy. Two coxsackievirus B3 (C...
متن کاملThe Effect of Enalapril on Brain Edema and Cytokine Production Following Transient Focal Cerebral Ischemia in Mice
Introduction: Cytokines production as one of the inflammatory pathways in CNS is responsible for most brain damages following ischemia. On the other hand, during inflammation and brain ischemia, most of the renin- angiotensin components (RAS) increase locally. While it is established that blockade of RAS especially AT1 receptors has a protective effect on ischemia, the interaction of cytokines ...
متن کاملCALL FOR PAPERS Integrative and Translational Physiology: Inflammation and Immunity in Organ System Physiology Impairment of heme biosynthesis induces short circadian period in body temperature rhythms in mice
Reiko Iwadate, Yoko Satoh, Yukino Watanabe, Hiroshi Kawai, Naomi Kudo, Yoichi Kawashima, Tadahiko Mashino, and Atsushi Mitsumoto Department of Pharmaceutical Sciences, Faculty of Pharmacy, Keio University, Minato-ku, Tokyo, Japan; Faculty of Pharmaceutical Sciences, Josai International University, Togane, Chiba, Japan; and Faculty of Pharmaceutical Sciences, Josai University, Sakado, Saitama, J...
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تاریخ انتشار 2013